39,160 research outputs found

    Health of people who travel to work: the effect of travel time and mode of transport on health: What have we learnt from the Kent and Medway health and lifestyle survey?

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    This is the first study of the health of people travelling to work. The paper describes a study from the 2001 Kent & Medway Health and Lifestyle Survey. It focusses on the health of people commuting to London and those working elsewhere who were travelling for more than 45 minutes

    Liquid-metal-piston MHD generator

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    Magnetohydrodynamic generator uses a slug or piston of liquid potassium as the working fluid. An expanding vapor of the metal is allowed to reciprocate the liquid-metal-piston through a magnetic field and the expansion energy is converted directly into electrical energy

    Regulation of anti-inflammatory gene expression in vascular endothelial cells by EPAC1

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    Suppressor of cytokine signalling 3 (SOCS3) is a potent inhibitor of pro-inflammatory pathways involved in atherogenesis and the development of neo-intimal hyperplasia (NIH), which contributes to the in-stent re-stenosis responsible for the failure of percutaneous coronary intervention (PCI) procedures. We have shown that cyclic AMP sensor EPAC1 triggers induction of the SOCS3 gene in vascular endothelial cells (VECs), thereby attenuating interleukin 6 (IL-6)-mediated pro-inflammatory signalling. We propose that EPAC1 localisation to the nuclear pore controls cyclic AMP-mediated activation of a C/EBPβ/c-Jun transcriptional complex, leading to SOCS3 induction and suppression of pro-inflammatory signalling. Future work in this area will involve an integrated approach to determine the wider significance of the EPAC1-C/EBPβ/c-Jun pathway in controlling human VEC function and identify new therapeutic targets for management of chronic inflammation in vascular settings

    The effect of three practice conditions on the consistency of chronic dysarthric speech

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    This study investigated whether it is possible for people with chronic dysarthria to adjust their articulation in three practice conditions. A speaker dependent, speech recognition system was used to compare participants' practice attempts with a model of a word made from previous recordings to give a recognition score. This score was used to indicate changes in production of practice words with different conditions. The three conditions were reading of written target words, visual feedback, and an auditory model followed by visual feedback. For eight participants with dysarthria, the ability to alter speech production was shown, together with a differential effect of the three conditions. Copying an auditory target gave significantly better recognition scores than just repeating the word. Visual feedback was no more effective than repetition alone. For four control participants, visual feedback did produce significantly better recognition scores than just repetition of written words, and the presence of an auditory model was Significantly more effective than visual feedback. Possible reasons for differences between conditions are discussed

    Higher diversity of Rhizobium leguminosarum biovar viciae populations in arable soils than in grass soils

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    The bacterial genetic diversity after long-term arable cultivation was compared with that under permanent grassland using replicated paired contrasts, Pea-nodulating Rhizobium leguminosarum populations were sampled from pairs of arable and grass sites at four locations in Yorkshire, United Kingdom, isolates were characterized using both chromosomal (16S-23S ribosomal DNA internal transcribed spacer PCR-restriction fragment length polymorphism) and plasmid (group-specific repC PCR amplification) markers. The diversities of chromosomal types, repC profiles, and combined genotypes were calculated using richness in types (adjusted to equal sample sizes by rarefaction), Shannon-Wiener index, and Simpson's index. The relative differences in diversity within each pair of sites were similar for all three diversity measures, Chromosomal types, repC profiles, and combined genotypes were each more diverse in arable soils than in grass soils at two of the four locations. The other comparisons showed no significant differences. We conclude that rhizobial diversity can be affected by differences between these two management regimens. Multiple regression analyses indicated that lower diversity was associated with high potential nitrogen and phosphate levels or with acidity

    Spectroradiometric calibration of the thematic mapper and multispectral scanner system

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    The results of an analysis that relates thematic mapper (TM) saturation level to ground reflectance, calendar date, latitude, and atmospheric condition is provided. A revised version of the preprint included with the last quarterly report is also provided for publication in the IEEE Transactions on Geoscience and Remote Sensing

    Spectroradiometric calibration of the Thematic Mapper and Multispectral Scanner system

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    The effects of the atmosphere on propagating radiation must be known in order to calibrate an in orbit sensor using ground based measurements. A set of model atmosphere parameters, applicable to the White Sands (New Mexico) area is defined with particular attention given to those parameters which are required as input to the Herman Code. The radial size distribution, refractive index, vertical distribution, and visibility of aerosols are discussed as well as the molecular absorbers in the visible and near IR wavelength which produce strong absorption lines. Solar irradiance is also considered

    Spectroradiometric calibration of the Thematic Mapper and Multispectral Scanner system

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    The results of analyses of Thematic Mapper (TM) images acquired on July 8 and October 28, 1984, and of a check of the calibration of the 1.22-m integrating sphere at Santa Barbara Research Center (SBRC) are described. The results obtained from the in-flight calibration attempts disagree with the pre-flight calibrations for bands 2 and 4. Considerable effort was expended in an attempt to explain the disagreement. The difficult point to explain is that the difference between the radiances predicted by the radiative transfer code (the code radiances) and the radiances predicted by the preflight calibration (the pre-flight radiances) fluctuate with spectral band. Because the spectral quantities measured at White Sands show little change with spectral band, these fluctuations are not anticipated. Analyses of other targets at White Sands such as clouds, cloud shadows, and water surfaces tend to support the pre-flight and internal calibrator calibrations. The source of the disagreement has not been identified. It could be due to: (1) a computational error in the data reduction; (2) an incorrect assumption in the input to the radiative transfer code; or (3) incorrect operation of the field equipment
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